ABSTRACT
Background: COVID-19 has been declared as a pandemic recently and has caused many deaths worldwide. Till date, no effective drug or vaccine is available against SARS-CoV-2. There is an urgent need to find effective alternative preventive and treatment strategies to deal with the SARS-CoV-2 outbreak. Objective(s): This communication proposes a new potential drug combination (repurposed) for prophylaxis and treatment of SARS-CoV-2. Methods and Materials: We performed a brief review of literature on a combination of Hydroxychloro-quine, Melatonin and Mercaptopurine for prophylaxis and treatment of Novel COVID-19 infection and also assessed their possible mechanism of action against SARS-CoV-2. Observation: Proposed combination seems to be safe, and the target is unlikely to develop resistance to this combination. Conclusion(s): This scientific review proposes potential candidate repurposed drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.Copyright © 2021 Bentham Science Publishers.
ABSTRACT
In 2019, a new variant of coronavirus emerged that put the whole world on a standstill due to its unprecedented spread and morbidity. Since then, scientists have been working on several theories to explain the origin and pathogenesis of the virus. Over this period of time, it has been observed clinically that individual variation exists in the way this virus infects people, its symptomatology and sequelae. The pathophysiology is still unclear. This review was taken up to consolidate all the available information until date about current theories of etiopathogenesis with an understanding of potential therapeutic targets on the mechanisms. This review also highlights the gray areas that need to be addressed in the future. Research papers published up to December 7, 2020 were included based on a search on PubMed, Google Scholar, etc., to get the latest relevant literature on this topic. Coronavirus expresses differently in different individuals, affecting different organ systems, and having variable severity. However, the underlying pathogenic mechanisms are not completely understood. Due to the lack of definite curative therapy, it is essential to explore the basic pathophysiology so as to develop more effective and target-based therapies in the future.
ABSTRACT
Background: Neck pain is a ubiquitous complaint leading to work place absenteeism, disabilities and disturbed sleep wake cycle in many young working and studying people. In ongoing covid scenario, since there is increased use of laptops and mobile phones facilitating work from home for employee and virtual learning for students, there has been increased prevalence of non-specific neck pain among the people due to prolonged fixed flexion posture. Neck pain has become the condition of major consideration since 45% of UG students had experienced neck pain in last 12 months. Aims and Objectives: to evaluate combined and individual effects of Therapeutic Ultrasound and Myofascial Release Technique on Quality of Life of students suffering from neck pain owing to virtual learning. Methods: The participant (n=33) will be recruited in study experiencing non-specific neck pain and meeting the inclusion criteria. Three groups will be formed such that the patient in Group A will receive treated with therapeutic ultrasound. Group B will be receiving treatment using Myofascial Release Technique and Group C will be treated using combined use of both Therapeutic Ultrasound and Myofascial release Technique. The protocol will cover 1 week of treatment. Regular assessment at 0,3rd and 7th day of week will be carried out. We will evaluate using Numerical Pain Rating Scale (NPRS), Neck Disability Index (NDI), and Range of motion of neck and Manual Muscle testing of cervical musculature. Results: The result of the study will provide affirmation on using combination therapy of Therapeutic Ultrasound and Myofascial Release Technique in people having nonspecific neck pain.